-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, DY2WOutJSc803R76++E//FH1l5BRMa4Wd6nuf9nSVIM9eDu7Np0wAV07erE7K591 h4Sf44dIzrM2dAaUbWu2vA== 0000950005-01-000050.txt : 20010205 0000950005-01-000050.hdr.sgml : 20010205 ACCESSION NUMBER: 0000950005-01-000050 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20010201 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: DYAX CORP CENTRAL INDEX KEY: 0000907562 STANDARD INDUSTRIAL CLASSIFICATION: SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731] IRS NUMBER: 043053198 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: SEC FILE NUMBER: 005-60267 FILM NUMBER: 1521810 BUSINESS ADDRESS: STREET 1: ONE KENDALL SQ BLDG 600 5TH FL CITY: CAMBRIDGE STATE: MA ZIP: 02139 MAIL ADDRESS: STREET 1: ONE KENDALL SQ BLDG 600 STREET 2: 5TH FL CITY: CAMBRIDGE STATE: MA ZIP: 02139 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ALTA PARTNERS CENTRAL INDEX KEY: 0001060013 STANDARD INDUSTRIAL CLASSIFICATION: [] IRS NUMBER: 943238854 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 BUSINESS PHONE: 4153624022 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 SC 13G 1 0001.txt SC 13G United States Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Amendment No. __)* Under the Securities Exchange Act of 1934 DYAX CORPORATION ----------------------------------------- (Name of Issuer) Common Stock ----------------------------------------- (Title of Class of Securities) 26746E103 ----------------------------------------- (CUSIP Number) December 31, 2000 - -------------------------------------------------------------------------------- (Date of Event That Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: |_| Rule 13d-1(b) |X| Rule 13d-1(c) |_| Rule 13d-1(d) * The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No. 26746E103 Page 2 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization California Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 1,376,147 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 1,376,147 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person CO - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No.26746E103 Page 3 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Partners, L.P. - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 855,393 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 855,393 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 855,393 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 4.49% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person PN - ------------------------------------------------------------------------------------------------------------
CUSIP No. 26746E103 Page 4 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Management Partners, LLC. - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 855,393 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 855,393 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 855,393 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 4.49% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person CO - ------------------------------------------------------------------------------------------------------------
CUSIP No. 26746E103 Page 5 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Dyax Chase Partners (Alta Bio), LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 488,512 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 488,512 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 488,512 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 2.56% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person CO - ------------------------------------------------------------------------------------------------------------
CUSIP No. 26746E103 Page 6 of 17 pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero BioPharma Partners, LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization California Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 32,242 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 32,242 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 32,242 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 0.17% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person CO - ------------------------------------------------------------------------------------------------------------
CUSIP No. 26746E103 Page 7 of 17 pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta/Chase BioPharma Management, LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power 488,512 Beneficially Owned By Each Reporting (6) Shared Voting Power -0- Person With (7) Sole Dispositive Power 488,512 (8) Shared Dispositive Power -0- (9) Aggregate Amount Beneficially Owned By Each Reporting Person 488,512 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 2.56% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person CO - ------------------------------------------------------------------------------------------------------------
CUSIP No. 26746E103 Page 8 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 26746E103 Page 9 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 26746E103 Page 10 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Daniel Janney - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 26746E103 Page 11 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alix Marduel - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 26746E103 Page 12 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 26746E103 Page 13 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Marino Polestra - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group (a) (b) X - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States Please see Attachment A - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power -0- Beneficially Owned By Each Reporting (6) Shared Voting Power 1,376,147 Person With (7) Sole Dispositive Power -0- (8) Shared Dispositive Power 1,376,147 (9) Aggregate Amount Beneficially Owned By Each Reporting Person 1,376,147 Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - ------------------------------------------------------------------------------------------------------------ (11) Percent Of Class Represented By Amount In Row (11) 7.22% Please see Attachment A - ------------------------------------------------------------------------------------------------------------ (12) Type Of Reporting Person IN - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
Item 1. (a) Name of Issuer: Dyax Corporation ("Issuer") (b) Address of Issuer's Principal Executive Offices: One Kendall Square, Building 600, Suite 623 Cambridge, MA 02139 Item 2. (a) Name of Person Filing: Alta Partners ("AP") Alta BioPharma Partners, L.P. ("ABP") Alta BioPharma Management Partners, LLC. ("ABMP") Alta Embarcadero BioPharma Partners, LLC ("AEBP") Dyax Chase Partners (Alta Bio), LLC ("DCP") Alta/Chase BioPharma Management, LLC ("ACMP") Jean Deleage ("JD") Garrett Gruener ("GG") Dan Janney ("DJ") Alix Marduel ("AM") Guy Nohra ("GN") Marino Polestra ("MP") (b) Address of Principal Business Office: One Embarcadero Center, Suite 4050 San Francisco, CA 94111 (c) Citizenship/Place of Organization: Entities: AP - California ABP - Delaware ABMP Delaware AEBP California DCP Delaware ACMP Delaware Individuals: JD United States GG United States DJ United States AM United States GN United States MP United States (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 26746E103 (f) Item 3. Not applicable. Item 4 Ownership.
Please see Attachment A - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- AP ABP ABMP AEBP DCP ACMP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 1,376,147 855,393 855,393 32,242 488,512 488,512 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 7.22% 4.49% 4.49% 0.17% 2.56% 2.56% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power 1,376,147 855,393 855,393 32,242 488,512 488,512 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power 1,376,147 855,393 855,393 32,242 488,512 488,512 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- JD GG DJ AM GN MP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 7.22% 7.22% 7.22% 7.22% 7.22% 7.22% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 1,376,147 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Item 5. Ownership of Five Percent or Less of a Class Not Applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification By signing below we certify that, to the best of our knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. EXHIBITS A: Joint Filing Statement Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: January 31, 2001
Alta Partners Alta BioPharma Partners, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------- ------------------------------- Jean Deleage, President Alix Marduel, Managing Director Alta BioPharma Management Partners, LLC Alta Embarcadero BioPharma Partners, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------- ------------------------------- Alix Marduel, Member Jean Deleage, Member Dyax Chase Partners (Alta Bio), LLC Alta/Chase BioPharma Management, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------- ------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra ----------------------- ------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Marino Polestra ----------------------- ------------------------------- Garrett Gruener Marino Polestra /s/ Daniel Janney /s/ Alix Marduel ----------------------- ------------------------------- Daniel Janney Alix Marduel
Exhibit A Agreement of Joint Filing We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us. Date: January 26, 2001
Alta Partners Alta BioPharma Partners, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------- ------------------------------- Jean Deleage, President Alix Marduel, Managing Director Alta BioPharma Management Partners, LLC Alta Embarcadero BioPharma Partners, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------- ------------------------------- Alix Marduel, Member Jean Deleage, Member Dyax Chase Partners (Alta Bio), LLC Alta/Chase BioPharma Management, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------- ------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra ----------------------- ------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Marino Polestra ----------------------- ------------------------------- Garrett Gruener Marino Polestra /s/ Daniel Janney /s/ Alix Marduel ----------------------- ------------------------------- Daniel Janney Alix Marduel
Attachment A Alta Partners provides investment advisory services to several venture capital funds including, Alta BioPharma Partners L.P., Dyax Chase Partners (AltaBio) LLC and Alta Embarcadero BioPharma Partners, LLC. Alta BioPharma Partners L.P. beneficially owns 855,393 shares of Common Stock. Dyax Chase Partners (AltaBio) LLC beneficially owns 488,512 shares of Common Stock. Alta Embarcadero BioPharma Partners, LLC beneficially owns 32,242 shares of Common Stock. The respective general partner and managing members of Alta BioPharma Partners, L.P., Dyax Chase Partners (AltaBio) LLC and Alta Embarcadero BioPharma Partners, LLC exercise sole voting and investment power with respect to the shares owned by such funds. The principals of Alta Partners are members of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and Alta/Chase BioPharma Management LLC (which is the managing member of Dyax Chase Partners (AltaBio), LLC) and Alta Embarcadero BioPharma Partners, LLC. As general partners and managing members of such entities, they may be deemed to share voting and investment powers for the shares held by the funds. The principals of Alta Partners disclaim beneficial ownership of all such shares held by the foregoing funds, except to the extent of their proportionate pecuniary interests therein. Alta Partners is a venture capital company with an office in San Francisco. Alta Partners is California Corporation. Alta BioPharma Partners, L.P. is a Delaware Limited Partnership, Dyax Chase Partners (AltaBio), LLC is a Delaware Limited Liability Company, and Alta Embarcadero BioPharma Partners, LLC is a California Limited Liability Company. Dr. Alix Marduel, a Director of the Company, is a managing member of the general partner of Alta BioPharma Partners, L.P. She disclaims beneficial ownership of all such shares held by all of the foregoing funds, except to the extent of their proportionate pecuniary interests therein. -----END PRIVACY-ENHANCED MESSAGE-----